Carotid artery stenting: analysis of 105 cases in high-risk patients

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Introduction Carotid Artery Stenting (CAS) has been recommended as an alternative to carotid endarterectomy (CEA) by some clinicians. However recently published clinical trials have reported 30-day stroke and death rates of 10-12%. This prompted a review of our experience with CAS in high-risk patients to document our results and guide further use of CAS. Methods From September 1996 to present, we have performed 105 CAS procedures in 63 (60%) men and 42 (40%) women, mean age 70 years (range 45-93). Indications for CAS included restenosis after prior CEA in 74 cases (67%), primary lesions in high-risk patients in 38 cases (28%) and carotid stenosis with prior ipsilateral radiation therapy in 8 cases (7%). Asymptomatic stenoses >80% were managed in 62 patients (61%), while symptomatic lesions were treated in 39 patients (39%). Results Technical success of CAS occurred in all cases. Mean severity of stenosis prior to CAS was 87 + 6 and 9 + 4% after CAS. Two deaths (1.9%, 1 reperfusion/intra-cerebral hemorrhage and 1 myocardial infarction 10-days after discharge) and one stroke (0.9%) were observed (30-day stroke and death 2.8%). Two transient neurological events occurred (1.9%). No cranial nerve deficits were noted. No neurological complications have been observed in the last 27 cases (26%). Conclusions A 30-day stroke and death rate of 2.8% in our experience demonstrates acceptability of CAS as an alternative to reoperation or primary CEA in high-risk patients. We recommend further clinical investigation of CAS and participation in clinical trials by vascular surgeons.